The store spans 2054sqm over three levels and offers the full line up of Uniqlo clothing, including its new Autumn/Winter collection and Ultra Light Down (ULD) range.
To celebrate, the brand has installed giant origami cranes in Queen St Mall, designed in collaboration with local artist, Jasmine Dowling.
It is the second Queensland Uniqlo store, with the other located at Indooroopilly.
Shoichi Miyasaka, CEO of Uniqlo Australia, said that since opening the first store in Melbourne in 2014 the brand has gained a huge following.